*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CY1483600
CHEMICAL NAME           : Benzeneacetamide,
                          N-(4-chlorophenyl)-N-(1-(1-methylethyl)-4-piperidinyl
                          )-
CAS REGISTRY NUMBER     : 59729-31-6
BEILSTEIN REFERENCE NO. : 0497568
REFERENCE               : 5-22-08-00059 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C22-H27-Cl-N2-O
MOLECULAR WEIGHT        : 370.96
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 4'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide
   * N-(4-Chlorophenyl)-N-(1-(1-methylethyl)-4-piperidinyl)benzeneacetamide
   * Lorcainide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Cardiac - pulse rate
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   33,157,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 395 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RMISDU International Congress and Symposium Series - Royal Society of
   Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E.
   60th St., New York, NY 10022)  No.1-   1978-  Volume(issue)/page/year:
   49,23,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RMISDU International Congress and Symposium Series - Royal Society of
   Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E.
   60th St., New York, NY 10022)  No.1-   1978-  Volume(issue)/page/year:
   49,23,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 483 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RMISDU International Congress and Symposium Series - Royal Society of
   Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E.
   60th St., New York, NY 10022)  No.1-   1978-  Volume(issue)/page/year:
   49,23,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RMISDU International Congress and Symposium Series - Royal Society of
   Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E.
   60th St., New York, NY 10022)  No.1-   1978-  Volume(issue)/page/year:
   49,23,1981
 
                            *** END OF RECORD ***