*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CX3072000
CHEMICAL NAME           : Benz(a)anthracene,
                          1,2,3,4-tetrahydro-3-alpha,4-beta-dihydroxy-1-alpha,2
                          -alpha-epoxy-, (E)-
CAS REGISTRY NUMBER     : 64598-80-7
LAST UPDATED            : 199410
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C18-H14-O3
MOLECULAR WEIGHT        : 278.32
WISWESSER LINE NOTATION : T E6 C6 B663 SO&&&TTJ PQ QQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * BA 3,4-Diol-1,2-epoxide l
   * BA 3,4-Diol-1,2-epoxide-2
   * Benz(a)anthracene 3,4-diol-1,2-epoxide-2
   * (+-)-(1R,2S,3R,4R)-3,4-Dihydro-3,4-dihydroxy-1,2-epoxybenz(a)anthracene
   *   (+-)-3-alpha,4-beta-Dihydroxy-1-alpha,2-alpha-epoxy-1,2,3,4-tetrahydrobe
     nz(a)anthracene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,1699,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 pmol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,1656,1983
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 150 pmol/plate
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 4,1631,1983
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 20 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,1656,1983

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation

 
                            *** END OF RECORD ***