*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CY1576247
CHEMICAL NAME           : Benzeneacetic acid,
                          4-chloro-alpha-ethyl-alpha-hydroxy-(2,3,5,7a-tetrahyd
                          ro-1-hydroxy- (1H)-pyrrolizin-7-yl)methyl ester,
                          N-oxide, (1R-(1-alpha,7(R*),7a-beta))-
CAS REGISTRY NUMBER     : 127441-92-3
LAST UPDATED            : 199406
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H22-Cl-N-O5
MOLECULAR WEIGHT        : 367.86
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 9-O-(R(-)-2-(4'-Chlorophenyl)-2-hydroxybutyryl)retronecine N-oxide
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 gm/kg/4W-I
TOXIC EFFECTS :
   Blood - macrocytosis
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   101,271,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg/9D-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Blood - macrocytosis
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   101,271,1989
 
                            *** END OF RECORD ***