*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AD0350000
CHEMICAL NAME           : Acetamidine, N,N'-bis(p-ethoxyphenyl)-
CAS REGISTRY NUMBER     : 101-93-9
BEILSTEIN REFERENCE NO. : 2702842
REFERENCE               : 4-13-00-01108 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C18-H22-N2-O2
MOLECULAR WEIGHT        : 298.42
WISWESSER LINE NOTATION : 2OR DNUY1&MR DO2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N,N'-Bis(p-ethoxyphenyl)acetamidine
   * N',N(sup 2)-Bis(p-ethoxyphenyl)acetamidine
   * N,N'-Bis(4-ethoxyphenyl)ethanimidamide monohydrochloride
   * Ethanimidamide, N,N'-bis(4-ethoxyphenyl)-
   * Fenacaine
   * Holocaine
   * Phenacaine
   * Tanicaine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 53 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
                            *** END OF RECORD ***