*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AD9310000
CHEMICAL NAME           : Acetanilide, 4'-(bis(2-chloroethyl)amino)-2-fluoro-
CAS REGISTRY NUMBER     : 1492-93-9
BEILSTEIN REFERENCE NO. : 2815229
REFERENCE               : 4-13-00-00138 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C12-H15-Cl2-F-N2-O
MOLECULAR WEIGHT        : 293.19
WISWESSER LINE NOTATION : G2N2GR DMV1F
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 4'-(Bis(2-chloroethyl)amino)-2-fluoroacetanilide
   * p-Fluoroacetylaminophenyl derivative of nitrogen mustard
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7916 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,167,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,167,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 9,492,1961
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 45 mg/kg
SEX/DURATION            : female 7-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - hepatobiliary system
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 9,492,1961
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 45 mg/kg
SEX/DURATION            : female 7-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 9,492,1961
 
                            *** END OF RECORD ***