*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CY8490000
CHEMICAL NAME           : Benzene, 1,4-bis(1-isocyanato-1-methylethyl)-
CAS REGISTRY NUMBER     : 2778-41-8
BEILSTEIN REFERENCE NO. : 2741545
LAST UPDATED            : 199710
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C14-H16-N2-O2
MOLECULAR WEIGHT        : 244.32
COMPOUND DESCRIPTOR     : Primary Irritant
SYNONYMS/TRADE NAMES :
   * Bis(isocyanatomethyl)durene
   * 1,4-Bis(1-isocyanato-1-methylethyl)benzene
   * Isocyanic acid, p-phenylenediisopropylidene ester
   * Isocyanic acid, alpha,alpha,alpha',alpha'-tetramethyl-p-xylylene ester
   * p-Tetramethylxylylene diisocyanate
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Severe
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,160,1992
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Kidney, Ureter, Bladder - incontinence
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,160,1992
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 220 mg/m3/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,160,1992
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,160,1992

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***