*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CY2625000
CHEMICAL NAME           : Benzene, 5-allyl-1-methoxy-2,3-(methylenedioxy)-
CAS REGISTRY NUMBER     : 607-91-0
BEILSTEIN REFERENCE NO. : 0166218
REFERENCE               : 5-19-02-00631 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C11-H12-O3
MOLECULAR WEIGHT        : 192.23
WISWESSER LINE NOTATION : T56 BO DO CHJ FO1 H2U1
COMPOUND DESCRIPTOR     : Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * 5-Allyl-1-methoxy-2,3-(methylenedioxy)benzene
   * 1,3-Benzodioxole, 4-methoxy-6-(2-propenyl)-
   * Myristicin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 5700 ug/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - euphoria
   Behavioral - hallucinations, distorted perceptions
REFERENCE :
   JNEUAY Journal of Neuropsychiatry.  (Chicago, IL)  V.1-5, 1959-64.  For
   publisher information, see BENPBG.  Volume(issue)/page/year: 2,205,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 30,563,1982
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Liver - fatty liver degeneration
REFERENCE :
   AMJPA6 American Journal of Pharmacy (1835-1936).  (Philadelphia, PA)
   V.1-108, 1835-1936.  Volume(issue)/page/year: 80,563,1909
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Liver - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AMJPA6 American Journal of Pharmacy (1835-1936).  (Philadelphia, PA)
   V.1-108, 1835-1936.  Volume(issue)/page/year: 80,563,1909
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Liver - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AMJPA6 American Journal of Pharmacy (1835-1936).  (Philadelphia, PA)
   V.1-108, 1835-1936.  Volume(issue)/page/year: 80,563,1909
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,1613,1984
 
                            *** END OF RECORD ***