*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CZ0400000
CHEMICAL NAME           : Benzene, chlorodimethyl(1-phenylethyl)-
CAS REGISTRY NUMBER     : 95719-24-7
LAST UPDATED            : 199603
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C16-H17-Cl
MOLECULAR WEIGHT        : 244.78
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Chlorodimethyl(1-phenylethyl)benzene
   * Monochlorophenylxylylethane
   * 1,1-Phenylmonochloroxylylethane
   * Xylene, chloro(alpha-methylbenzyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2129 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 58(1),30,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1488 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 58(1),30,1993
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15756 mg/kg/30D-I
TOXIC EFFECTS :
   Liver - liver function tests impaired
REFERENCE :
   AZMZA6 Azerbaidzhanskii Meditsinskii Zhurnal.  Azerbaidzhan Medical Journal.
   (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  1928-41; 1955-
   Volume(issue)/page/year: 61(9),3,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 150 mg/kg/30D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Blood - changes in leukocyte (WBC) count
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 58(1),30,1993
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE                    : 150 mg/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 58(1),30,1993
 
                            *** END OF RECORD ***