*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CZ0525000
CHEMICAL NAME : Benzene, 1-chloro-2,4-dinitro-
CAS REGISTRY NUMBER : 97-00-7
LAST UPDATED : 199710
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C6-H3-Cl-N2-O4
MOLECULAR WEIGHT : 202.56
WISWESSER LINE NOTATION : WNR BG ENW
COMPOUND DESCRIPTOR : Drug
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* CDNB
* 1-Chloor-2,4-dinitrobenzeen
* 1-Chlor-2,4-dinitrobenzene
* 1-Chloro-2,4-dinitrobenzene
* 4-Chloro-1,3-dinitrobenzene
* 6-Chloro-1,3-dinitrobenzene
* 1-Chloro-2,4-dinitrobenzol
* 1-Cloro-2,4-dinitrobenzene
* 1,3-Dinitro-4-chlorobenzene
* 2,4-Dinitrochlorobenzene
* 2,4-Dinitro-1-chlorobenzene
* Dinitrochlorobenzol
* DNCB
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human
DOSE/DURATION : 30 ug
REFERENCE :
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis.
(Munksgaard International Pub., c/o Publications Expediting Inc., 200
Meacham Ave., Elmont, NY 11003) V.1- 1975- Volume(issue)/page/year:
2,247,1976
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 ug/24H
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 mg/24H
REACTION SEVERITY : Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,600,1986
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 50 ug/24H
REACTION SEVERITY : Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,600,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(2),48,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 280 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - peritonitis
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 17,217,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 130 mg/kg
TOXIC EFFECTS :
Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
23,95,1962
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2340 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Liver - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(2),48,1988
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 ug/m3/4H/17W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 29(8),59,1985
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 3 ug/plate
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.82- 1960- Volume(issue)/page/year: 121,348,1985
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 ug/plate
REFERENCE :
ADREDL Archives of Dermatological Research. (Springer-Verlag New York,
Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.253- 1975-
Volume(issue)/page/year: 266,315,1979
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 131,215,1984
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 30 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,239,1983
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 10 mg/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
45,307,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83616
No. of Facilities: 174 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1221 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83616
No. of Facilities: 82 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 170 (estimated)
No. of Female Employees: 14 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***