*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CZ3075000
CHEMICAL NAME           : 1,3-Benzenedicarboxamide,
                          5,5'-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis
                          (N,N'- bis(2,3-dihydroxypropyl)-2,4,6-triiodo-
CAS REGISTRY NUMBER     : 92339-11-2
LAST UPDATED            : 199806
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C35-H44-I6-N6-O15
SYNONYMS/TRADE NAMES :
   * Iodixanol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >42757 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - hemorrhage
REFERENCE :
   ARASA5 Acta Radiologica, Supplementum.  (Acta Radiologica, POB 7449, S-10391
   Stockholm, Sweden) No.1-    1921-  Volume(issue)/page/year: 399,69,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30512 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   ARASA5 Acta Radiologica, Supplementum.  (Acta Radiologica, POB 7449, S-10391
   Stockholm, Sweden) No.1-    1921-  Volume(issue)/page/year: 399,69,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 73228 mg/kg/3W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - urine volume increased
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   ARASA5 Acta Radiologica, Supplementum.  (Acta Radiologica, POB 7449, S-10391
   Stockholm, Sweden) No.1-    1921-  Volume(issue)/page/year: 399,69,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 54921 mg/kg/3W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   ARASA5 Acta Radiologica, Supplementum.  (Acta Radiologica, POB 7449, S-10391
   Stockholm, Sweden) No.1-    1921-  Volume(issue)/page/year: 399,69,1995
 
                            *** END OF RECORD ***