*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CZ6310000
CHEMICAL NAME           : Benzene, 2,6-diisocyanato-1-methyl-
CAS REGISTRY NUMBER     : 91-08-7
BEILSTEIN REFERENCE NO. : 2211546
REFERENCE               : 4-13-00-00259 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 20
MOLECULAR FORMULA       : C9-H6-N2-O2
MOLECULAR WEIGHT        : 174.17
WISWESSER LINE NOTATION : OCNR B1 CNCO
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * 2,6-Diisocyanato-1-methylbenzene
   * 2,6-Diisocyanatotoluene
   * Isocyanic acid, 2-methyl-meta-phenylene ester
   * 2-Methyl-meta-phenylene diisocyanate
   * 2-Methyl-meta-phenylene isocyanate
   * 2,6-TDI
   * Toluene 2,6-diisocyanate
   * 2,6-Toluene diisocyanate
   * Tolylene 2,6-diisocyanate
   * meta-Tolylene diisocyanate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 50 ppb
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year:
   19,364,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-251,1986
 
TYPE OF TEST            : Specific locus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 25 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   17,196,1991
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 600 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,133,1989
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 300 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,133,1989

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 39,287,1986

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 39,287,1986

   IARC Cancer Review:Group 2B
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-DENMARK:TWA 0.005 ppm (0.035 mg/m3);Carcinogen JAN 1993
   
   OEL-GERMANY:TWA 0.01 ppm (0.07 mg/m3) JAN 1993
   
   OEL-SWITZERLAND:TWA 0.005 ppm (0.04 mg/m3);STEL 0.01 ppm JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.02 mg/m3;STEL 0.07 mg/m3 JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M0788
       No. of Facilities: 609 (estimated)
       No. of Industries: 14
       No. of Occupations: 18
       No. of Employees: 15830 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M0788
       No. of Facilities: 415 (estimated)
       No. of Industries: 12
       No. of Occupations: 22
       No. of Employees: 2872 (estimated)
       No. of Female Employees: 284 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521
   
   OSHA ANALYTICAL METHOD #42

 
                            *** END OF RECORD ***