*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CZ8957500
CHEMICAL NAME           : 1,2-Benzenediol,
                          4-(1-hydroxy-2-((2-(1H-indol-3-yl)-1-methylethyl)amin
                          o)ethyl)-, (R-(R*,R*))-2,3-dihydroxybutanedioate
                          (salt)
CAS REGISTRY NUMBER     : 5781-48-6
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H22-N2-O3.xC4-H6-O6
MOLECULAR WEIGHT        : 1377.13
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * levo-3-(2-(2-Hydroxy-2-(3,4-dihydroxyphenyl)ethylamino)propyl)indole  
   tartrate
   * SC 10049
   * SC 13674
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 139 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP elevation not characterized in autonomic section
   Biochemical - Metabolism (Intermediary) - other
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 133,90,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 249 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 133,90,1961
 
                            *** END OF RECORD ***