*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DA0292500
CHEMICAL NAME           : Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-,
                          hydrochloride, (R)-
CAS REGISTRY NUMBER     : 14611-52-0
OTHER CAS REGISTRY NOS. : 40602-63-9
LAST UPDATED            : 199606
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C13-H17-N.Cl-H
MOLECULAR WEIGHT        : 223.77
WISWESSER LINE NOTATION : 1UU2N1&Y1&1R &GH --
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * (-)-Deprenil hydrochloride
   * (-)-Deprenyl hydrochloride
   * l-Deprenyl hydrochloride
   * (-)-N,alpha-Dimethyl-N-2-propynylbenzeneethanamine hydrochloride
   * (-)-(R)-N,alpha-Dimethyl-N-2-propynylphenethylamine monohydrochloride
   * (-)-E-250
   * Eldepryl
   * FPF1100
   * Jumex
   * (-)-Phenylisopropylmethylpropynylamine
   * Selegiline hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APACAB Acta Physiologica Academiae Scientiarum Hungaricae.  (Budapest,
   Hungary)  V.1-60, 1950-82.  Volume(issue)/page/year: 32,377,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 81 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APACAB Acta Physiologica Academiae Scientiarum Hungaricae.  (Budapest,
   Hungary)  V.1-60, 1950-82.  Volume(issue)/page/year: 32,377,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 121 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APACAB Acta Physiologica Academiae Scientiarum Hungaricae.  (Budapest,
   Hungary)  V.1-60, 1950-82.  Volume(issue)/page/year: 32,377,1967
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1904 mg/kg
SEX/DURATION            : male 9 week(s) pre-mating
                          female 2 week(s) pre-mating  - 3 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 19(Suppl
   1),93,1994
 
                            *** END OF RECORD ***