*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DA9760000
CHEMICAL NAME           : Benzenesulfonamide,
                          4-amino-N-(thioxo(tricyclo(3.3.1.1(sup
                          3,7))dec-1-ylamino)methyl)-
CAS REGISTRY NUMBER     : 70889-42-8
BEILSTEIN REFERENCE NO. : 2899554
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H23-N3-O2-S2
MOLECULAR WEIGHT        : 365.55
WISWESSER LINE NOTATION : L66 B6/B-H/DI A B- C 1B ITJ BMYUS&MSWR DZ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-Adamantyl-3-((4-aminophenyl)sulfonyl)thiourea
   * 4-Amino-N-(thioxo(tricyclo(3.3.1.1(sup  
   3,7))dec-1-ylamino)methyl)benzenesulfonamide
   * Ro-21-4923
   * Urea, 1-(1-adamantyl)-3-((4-aminophenyl)sulfonyl)-2-thio-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 22,1009,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 775 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 22,1009,1979
 
                            *** END OF RECORD ***