*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DB1296000
CHEMICAL NAME           : Benzenesulfonamide,
                          N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-p-methoxy-
CAS REGISTRY NUMBER     : 3567-26-8
BEILSTEIN REFERENCE NO. : 0295171
REFERENCE               : 4-27-00-08085 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C13-H17-N3-O3-S2
MOLECULAR WEIGHT        : 327.45
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)-p-methoxybenzenesulfonamide
   * 2-p-Methoxybenzenesulfonamido-5-tert-butyl-1,3,4-thiadiazole
   * Terbuzole
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1150 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Endocrine - hypoglycemia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   4,631,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Endocrine - hypoglycemia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   4,631,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Endocrine - hypoglycemia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   4,631,1962
 
                            *** END OF RECORD ***