*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DB5044530
CHEMICAL NAME           : Benzenesulfonic acid,
                          2,2'-(4,4'-biphenylylenedivinylene)di-, disodium salt
CAS REGISTRY NUMBER     : 27344-41-8
LAST UPDATED            : 199710
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C28-H20-O6-S2.2Na
MOLECULAR WEIGHT        : 562.58
WISWESSER LINE NOTATION : WSO&R B1U1R DR D1U1R BSWO &-NA- 2
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Benzenesulfonic acid,  
   2,2'-((1,1'-biphenyl)-4,4'-diyldi-2,1-ethenediyl)bis-, disodium salt
   * Disodium 4,4'-bis(2-sulfostyryl)biphenyl
   * FBA 351
   * Stilbene 3
   * Tinopal CBS
   * Tinopal CBS-X
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Severe
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974
 
TYPE OF TEST            : Rinsed with water
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/2S
REACTION SEVERITY       : Mild
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5580 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4920 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (104),45,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 110 mg/kg
SEX/DURATION            : female 6-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1139
       No. of Facilities: 768 (estimated)
       No. of Industries: 12
       No. of Occupations: 20
       No. of Employees: 57765 (estimated)
       No. of Female Employees: 46384 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***