*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DB7070000
CHEMICAL NAME           : Benzenesulfonic acid,
                          2-hydroxy-5-(((4-methyphenyl)sulfonyl)oxy)-, compd.
                          with piperazine (1:1)
CAS REGISTRY NUMBER     : 57775-27-6
LAST UPDATED            : 199406
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C13-H12-O7-S2.C4-H10-N2
MOLECULAR WEIGHT        : 430.53
WISWESSER LINE NOTATION : WSQR BQ EOSWR D1 &T6M DMTJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * A 585
   * Diethylenediamine sultosylate
   * 2-Hydroxy-5-(((4-methylphenyl)sulfonyl)oxy)benzenesulfonic acid  
   piperazine salt
   * 2-Hydroxy-5-tosyloxybenzenesulfonic acid piperazine salt
   * Mimedran
   * Piperazine sultosilate
   * Sultosilato de piperacina
   * Sultosilic acid, piperazine salt
   * 5-Tosiloxi 2-hidroxibenceno sulfonato de piperacina
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >11 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFTOD7 Archivos de Farmacologia y Toxicologia.  (Universidad Complutense,
   Facultad de Medicina, Departamento Coordinado de Farmacologia, Ciudad
   Universitaria, Madrid 3, Spain)  V.1-    1975-  Volume(issue)/page/year:
   5,281,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1272 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFTOD7 Archivos de Farmacologia y Toxicologia.  (Universidad Complutense,
   Facultad de Medicina, Departamento Coordinado de Farmacologia, Ciudad
   Universitaria, Madrid 3, Spain)  V.1-    1975-  Volume(issue)/page/year:
   5,281,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 11,43,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 834 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFTOD7 Archivos de Farmacologia y Toxicologia.  (Universidad Complutense,
   Facultad de Medicina, Departamento Coordinado de Farmacologia, Ciudad
   Universitaria, Madrid 3, Spain)  V.1-    1975-  Volume(issue)/page/year:
   5,281,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 605 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFTOD7 Archivos de Farmacologia y Toxicologia.  (Universidad Complutense,
   Facultad de Medicina, Departamento Coordinado de Farmacologia, Ciudad
   Universitaria, Madrid 3, Spain)  V.1-    1975-  Volume(issue)/page/year:
   5,281,1979
 
                            *** END OF RECORD ***