*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DB7084000
CHEMICAL NAME           : Benzenesulfonic acid,
                          4-((2-hydroxy-1-naphthalenyl)azo)-, monosodium salt
CAS REGISTRY NUMBER     : 633-96-5
OTHER CAS REGISTRY NOS. : 75025-97-7
LAST UPDATED            : 199710
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C16-H12-N2-O4-S.Na
MOLECULAR WEIGHT        : 351.35
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Acid Leather Orange Extra
   * Acid Leather Orange Extra G
   * Acid Leather Orange Extra PRW
   * Acid Orange
   * Acid Orange 7
   * Acid Orange A
   * Acid Orange II
   * Acilan Orange II
   * Airedale Orange II
   * Amacid Orange Y
   * Atul Acid Orange II
   * Betanaphthol Orange
   * Brasilan Orange A
   * Bucacid Orange A
   * Calcocid Orange Y
   * Certiqual Orange II
   * C.I. 15510
   * C.I. Acid Orange 7
   * C.I. Acid Orange 7, monosodium salt
   * Colacid Orange
   * Curol Orange
   * D and C Orange No. 4
   * Diacid Orange II
   * Erio Orange II
   * Fenazo Orange
   * Hidacid Orange II
   * Hispacid Orange AF
   * p-((2-Hydroxy-1-naphthyl)azo)benzenesulfonic acid sodium salt
   * Java Orange II
   * Kiton Orange II
   * Kromon Lake Orange Toner
   * Lake Orange A
   * Lake Orange II YS
   * Leather Orange Extra
   * Lurazol Orange E
   * Lutetia Orange 3JR
   * Mandarin G
   * Naphthalene Lake Orange G
   * Naphthalene Orange G
   * Naphthol Orange
   * beta-Naphthol orange
   * 2-Naphthol Orange II
   * beta-Naphthyl orange
   * Naphtocard Orange II
   * Neklacid Orange II
   * No. 177 Orange Lake
   * Nubilon Orange R
   * 11550 Orange
   * Orange Extra N
   * Orange Extra P
   * Orange II
   * Orange IIC
   * Orange II For Lakes
   * Orange IIP
   * Orange IIS
   * Orange Iism
   * Orange II Special For Lacquer
   * Orange No. 205
   * Orange 2 sodium salt
   * Orange Toner GRT
   * Orange Y
   * Orange YA
   * Orange YZ
   * Oranz kysela 7
   * Peeracid Orange II
   * Perca Orange GR
   * Persian Orange
   * Persian Orange Lake
   * Persian Orange X
   * Pure Orange II S
   * Rifa Acid Orange II
   * Sanyo Gum Orange A
   * Solar Orange
   * Special Orange GR
   * Special Orange H
   * Symuler Orange Lake 43
   * Symulon Acid Orange II
   * Tangarine Lake X-917
   * Tertracid Orange II
   * Tropaeolin ooo
   * Tropaeolin ooo 2
   * Vondacid Orange II
   * Wool Orange A
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 gm/kg/43W-C
TOXIC EFFECTS :
   Liver - other changes
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 17,1100,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 240 mg/kg/3D-I
TOXIC EFFECTS :
   Liver - other changes
   Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
   TIHEEC Toxicology and Industrial Health.  (Princeton Scientific Pub. Co.,
   POB 2155, Princeton, NJ 08540)  V.1-    1985-  Volume(issue)/page/year:
   8,63,1992
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 gm/kg
SEX/DURATION            : male 43 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 17,1100,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intratesticular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 15,1215,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 12 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 249,265,1991

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M1433
       No. of Facilities: 4422 (estimated)
       No. of Industries: 42
       No. of Occupations: 44
       No. of Employees: 43457 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M1433
       No. of Facilities: 3061 (estimated)
       No. of Industries: 22
       No. of Occupations: 31
       No. of Employees: 38768 (estimated)
       No. of Female Employees: 14382 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine
   reversion-Ames test
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***