*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DB7085000
CHEMICAL NAME           : Benzenesulfonic acid, p-((4-hydroxy-1-naphthyl)azo)-,
                          sodium salt
CAS REGISTRY NUMBER     : 523-44-4
OTHER CAS REGISTRY NOS. : 67621-59-4
LAST UPDATED            : 199701
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C16-H11-N2-O4-S.Na
MOLECULAR WEIGHT        : 350.34
WISWESSER LINE NOTATION : L66J BQ ENUNR DSWQ &-NA-
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acid Leather Orange I
   * Acid Orange I
   * Acid phosphine CL
   * A.F. Orange No. 1
   * Aizen Food Orange No. 1
   * Aizen Naphthol Orange I
   * Aizen Orange I
   * Certiqual Orange I
   * C.I. 150
   * C.I. 14600
   * C.I. Acid Orange 20
   * C.I. Acid Orange 20, monosodium salt
   * Dye Orange No. 1
   * Egacid Orange GG
   * Elgacid Orange 2G
   * Eniacid Orange I
   * Ext D and C Orange No. 3
   * External D and C Orange No. 3
   * Extract D and C Orange No. 3
   * FD and C Orange No. 1
   * FDC Orange I
   * Hispacid Orange 1
   * 4-((4-Hydroxy-1-naphthalenyl)azo)benzenesulfonic acid, monosodium salt
   * 4-((4-Hydroxy-1-naphthalenyl)azo)benzenesulphonic acid, monosodium salt
   * p-((4-Hydroxy-1-naphthyl)azo)benzenesulfonic acid, monosodium salt
   * p-((4-Hydroxy-1-naphthyl)azo)benzenesulfonic acid, sodium salt
   * p-((4-Hydroxy-1-naphthyl)azo)benzenesulphonic acid, monosodium salt
   * p-((4-Hydroxy-1-naphthyl)azo)benzenesulphonic acid, sodium salt
   * Java Orange I
   * Nankai Acid Orange I
   * Naphthalene Orange I
   * Naphthol Orange
   * alpha-Naphthol orange
   * Neklacid Orange 1
   * 1333 Orange
   * Orange I
   * Orange I Extra Conc. A Export
   * Orange IM
   * Orange I, sodium salt
   * Orange S
   * Oranz I
   * Oranz kysela 20
   * Schultz No. 185
   * Sodium azo-alpha-naphtholsulfanilate
   * Sodium azo-alpha-naphtholsulphanilate
   * 4-p-Sulfophenylazo-1-naphthol monosodium salt
   * 4-p-Sulphophenylazo-1-naphthol, monosodium salt
   * Tertracid Orange I
   * Tropaeolin 1
   * Tropaeolin OOO No. 1
   * Tropeolin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 38B,67,1966
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 546 gm/kg/2Y-C
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 15,404,1956
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9360 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 16,367,1957
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 600 umol/L
REFERENCE :
   SKEZAP Shokuhin Eiseigaku Zasshi.  Food Hygiene Journal.  (Nippon Shokuhin
   Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
   150, Japan)  V.1-    1960-  Volume(issue)/page/year: 12,298,1971

                              *** REVIEWS ***
 
   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 8,173,1975

   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 8,173,1975

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

   TOXICOLOGY REVIEW
   ARVPAX Annual Review of Pharmacology.  (Palo Alto, CA)  V.1-15, 1961-75. For
   publisher information, see ARPTDI.  Volume(issue)/page/year: 14,127,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X8767
       No. of Facilities: 36 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 896 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***