*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : DB7085000 CHEMICAL NAME : Benzenesulfonic acid, p-((4-hydroxy-1-naphthyl)azo)-, sodium salt CAS REGISTRY NUMBER : 523-44-4 OTHER CAS REGISTRY NOS. : 67621-59-4 LAST UPDATED : 199701 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C16-H11-N2-O4-S.Na MOLECULAR WEIGHT : 350.34 WISWESSER LINE NOTATION : L66J BQ ENUNR DSWQ &-NA- COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * Acid Leather Orange I * Acid Orange I * Acid phosphine CL * A.F. Orange No. 1 * Aizen Food Orange No. 1 * Aizen Naphthol Orange I * Aizen Orange I * Certiqual Orange I * C.I. 150 * C.I. 14600 * C.I. Acid Orange 20 * C.I. Acid Orange 20, monosodium salt * Dye Orange No. 1 * Egacid Orange GG * Elgacid Orange 2G * Eniacid Orange I * Ext D and C Orange No. 3 * External D and C Orange No. 3 * Extract D and C Orange No. 3 * FD and C Orange No. 1 * FDC Orange I * Hispacid Orange 1 * 4-((4-Hydroxy-1-naphthalenyl)azo)benzenesulfonic acid, monosodium salt * 4-((4-Hydroxy-1-naphthalenyl)azo)benzenesulphonic acid, monosodium salt * p-((4-Hydroxy-1-naphthyl)azo)benzenesulfonic acid, monosodium salt * p-((4-Hydroxy-1-naphthyl)azo)benzenesulfonic acid, sodium salt * p-((4-Hydroxy-1-naphthyl)azo)benzenesulphonic acid, monosodium salt * p-((4-Hydroxy-1-naphthyl)azo)benzenesulphonic acid, sodium salt * Java Orange I * Nankai Acid Orange I * Naphthalene Orange I * Naphthol Orange * alpha-Naphthol orange * Neklacid Orange 1 * 1333 Orange * Orange I * Orange I Extra Conc. A Export * Orange IM * Orange I, sodium salt * Orange S * Oranz I * Oranz kysela 20 * Schultz No. 185 * Sodium azo-alpha-naphtholsulfanilate * Sodium azo-alpha-naphtholsulphanilate * 4-p-Sulfophenylazo-1-naphthol monosodium salt * 4-p-Sulphophenylazo-1-naphthol, monosodium salt * Tertracid Orange I * Tropaeolin 1 * Tropaeolin OOO No. 1 * Tropeolin *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 38B,67,1966 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 546 gm/kg/2Y-C TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 15,404,1956 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9360 mg/kg/2Y-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 16,367,1957 ** MUTATION DATA ** TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 600 umol/L REFERENCE : SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960- Volume(issue)/page/year: 12,298,1971 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,173,1975 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,173,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8767 No. of Facilities: 36 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 896 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***