*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DB7180000
CHEMICAL NAME           : Benzenesulfonic acid,
                          5-(2H-naphtho(1,2-d)triazol-2-yl)-2-(2-phenylethenyl)
                          -, sodium salt
CAS REGISTRY NUMBER     : 6416-68-8
LAST UPDATED            : 199701
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C24-H16-N3-O3-S.Na
MOLECULAR WEIGHT        : 449.48
WISWESSER LINE NOTATION : T B566 CNNNJ DR D1U1R& CSWO &-NA-
COMPOUND DESCRIPTOR     : Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * C.I. 40645
   * C.I. Fluorescent Brightener 46
   * C.I. Fluorescent Brightening Agent 46, sodium salt
   * Fluorescent brightener 46
   * 2H-Naphtho(1,2-d)triazole, 2-(4-(2-phenylethenyl)-3-sulfophenyl)-, sodium 
    salt
   * Sodium 4-(2H-naphtho(1,2-d)triazol-2-yl)stilbene-2-sulfonate
   * Sodium 2-(4-styryl-3-sulfophenyl)-2H-naphtho-(1,2-d)-triazole
   * 2-Stilbenesulfonic acid, 4-(2H-naphtho(1,2-d)triazol-2-yl)-, sodium salt
   * Tinopal RBS
   * Tinopal RBS 200
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Moderate
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974
 
TYPE OF TEST            : Rinsed with water
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/2S
REACTION SEVERITY       : Mild
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Mild
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >21500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   5,176,1963
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4500 mg/m3/4H
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   5,176,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 4500 mg/kg/90D-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - peritonitis
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - T0955
       No. of Facilities: 141 (estimated)
       No. of Industries: 2
       No. of Occupations: 3
       No. of Employees: 949 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***