*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DC2100100
CHEMICAL NAME           : Benzene, 1,3,5-trichloro-
CAS REGISTRY NUMBER     : 108-70-3
LAST UPDATED            : 199710
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C6-H3-Cl3
MOLECULAR WEIGHT        : 181.44
WISWESSER LINE NOTATION : GR CG EG
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * s-Trichlorobenzene
   * sym-Trichlorobenzene
   * 1,3,5-Trichlorobenzene
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   48RKAL "Industrial and Environmental Xenobiotics: Metabolism and
   Pharmacokinetics of Organic Chemicals and Metals, Proceedings of an
   International Conference, Prague, 1980," Gut, I., et al., Berlin, Fed. Rep,
   Ger., Springer-Verlag, 1981  Volume(issue)/page/year: -,389,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: UCRL-13701
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,111,1987
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7380 mg/kg/13W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 11,11,1988
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 10 ppm
REFERENCE :
   EVETBX Environmental Entomology.  (Entomological Soc. of America, 4603
   Calvert Rd., College Park, MD 20740)  V.1-    1972- Volume(issue)/page/year:
   2,1029,1973
 
TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 10 ppm
REFERENCE :
   EVETBX Environmental Entomology.  (Entomological Soc. of America, 4603
   Calvert Rd., College Park, MD 20740)  V.1-    1972- Volume(issue)/page/year:
   2,1029,1973
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 425 mg/kg/24H
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,111,1987

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M2497
       No. of Facilities: 60 (estimated)
       No. of Industries: 3
       No. of Occupations: 8
       No. of Employees: 1673 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: TRP reversion
   
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA
   without S9
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   47,26992,82

   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***