*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DC4580000
CHEMICAL NAME : 1,2,4-Benzenetriol, 5-(2-aminoethyl)-
CAS REGISTRY NUMBER : 1199-18-4
BEILSTEIN REFERENCE NO. : 2211011
REFERENCE : 4-13-00-02916 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C8-H11-N-O3
MOLECULAR WEIGHT : 169.20
WISWESSER LINE NOTATION : Z2R BQ DQ EQ
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 6-Hydroxydopamine
* Oxidopamine
* 2,4,5-Trihydroxyphenethylamine
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 400 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 26,518,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - rat
DOSE : 2 mg/kg
SEX/DURATION : female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 26,518,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - rat
DOSE : 1600 ug/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
Reproductive - Paternal Effects - other effects on male
REFERENCE :
KHKKA3 Kachiku Hanshoku Kenkyu Kaishi. Journal of the Society of Animal
Reproduction. (Tokyo, Japan) V.1-22, 1955-77. For publisher information,
see KHZADH. Volume(issue)/page/year: 21,76,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 400 mg/kg
SEX/DURATION : female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 29,576,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rabbit
DOSE : 3 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,189,1974
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050,
Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
Volume(issue)/page/year: 45,327,1981
*** END OF RECORD ***