*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DC8450000
CHEMICAL NAME           : Benzhydrol,
                          alpha-(2-(dimethylamino)-1-methylethyl)-2-methyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 1477-79-8
LAST UPDATED            : 199012
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H25-N-O.Cl-H
MOLECULAR WEIGHT        : 319.91
WISWESSER LINE NOTATION : 1N1&1Y1&XQR&R &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzeneethanol,  
   alpha-(2-(dimethylamino)-1-methylethyl)-2-methyl-alpha-phenyl-, HCl
   * 3-Dimethylamino-2-methyl-1-phenyl-o-tolylpropanol hydrochloride
   * SKF 70463-A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 185 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 17,509,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 245 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 17,509,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - anticonvulsant
   Behavioral - alteration of classical conditioning
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,836,1965
 
                            *** END OF RECORD ***