*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : DD1751000 CHEMICAL NAME : Benzidine, 2,2',5,5'-tetrachloro- CAS REGISTRY NUMBER : 15721-02-5 BEILSTEIN REFERENCE NO. : 3364286 REFERENCE : 3-13-00-00447 (Beilstein Handbook Reference) LAST UPDATED : 199701 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C12-H8-Cl4-N2 MOLECULAR WEIGHT : 322.02 WISWESSER LINE NOTATION : ZR BG EG DR DZ CG FG COMPOUND DESCRIPTOR : Tumorigen SYNONYMS/TRADE NAMES : * (1,1'-Biphenyl)-4,4'-diamine, 2,2',5,5'-tetrachloro- * Tetrachlorobenzidine * 2,2',5,5'-Tetrachlorobenzidine * 3,3',6,6'-Tetrachlorobenzidine * 2,2',5,5'-Tetrachloro-(1,1'-biphenyl)-4,4'-diamine * 2,2',5,5'-Tetrachloro-4,4'-diaminodiphenyl *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 54 mg/kg/43W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - lymphoma, including Hodgkin's disease REFERENCE : JMEJAS Jikeikai Medical Journal. (Jikei Univ. School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1954- Volume(issue)/page/year: 25,123,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 36 mg/kg/43W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - lymphoma, including Hodgkin's disease REFERENCE : JMEJAS Jikeikai Medical Journal. (Jikei Univ. School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1954- Volume(issue)/page/year: 25,123,1978 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 gm/kg/43W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors REFERENCE : IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,141,1982 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 900 gm/kg/43W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors REFERENCE : IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,141,1982 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,141,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,141,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***