*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : DB2780000 CHEMICAL NAME : Benzenesulfonamide, N-(5-isobutyl-1,3,4-thiadiazol-2-yl)-p-methoxy- CAS REGISTRY NUMBER : 3567-08-6 BEILSTEIN REFERENCE NO. : 0295174 REFERENCE : 4-27-00-08084 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C13-H17-N3-O3-S2 MOLECULAR WEIGHT : 327.45 WISWESSER LINE NOTATION : T5NN DSJ CMSWR DO1& E1Y1&1 COMPOUND DESCRIPTOR : Tumorigen Drug SYNONYMS/TRADE NAMES : * 2-(p-Anisylsulfonamido)-5-isobutyl-1,3,4-thiadiazole * 8002 CB * FWH 114 * Glysobuzole * 5-Isobutyl-2-p-methoxybenzenesulfonamido-1,3,4-thiadiazole * Isobuzole * 2-(p-Methoxybenzenesulfonamido)-5-isobutyl-1,3,4-thiadiazole * Stabinol * 1,3,4-Thiadiazole, 5-isobutyl-2-(p-methoxybenzenesulfonamido)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 534 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 468 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - ataxia Endocrine - hypoglycemia Nutritional and Gross Metabolic - body temperature decrease REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,631,1962 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - muscle weakness Gastrointestinal - nausea or vomiting REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 214 gm/kg/52W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 *** REVIEWS *** TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** END OF RECORD ***