*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DD6495000
CHEMICAL NAME           : 2-Benzimidazolecarbamic acid, 5-butyl-, methyl ester
CAS REGISTRY NUMBER     : 14255-87-9
LAST UPDATED            : 199306
DATA ITEMS CITED        : 23
MOLECULAR FORMULA       : C13-H17-N3-O2
MOLECULAR WEIGHT        : 247.33
WISWESSER LINE NOTATION : T56 BM DNJ CMVO1 G4
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 5-Butyl-2-benzimidazolecarbamic acid methyl ester
   * N-(Butyl-5, benzimidazolyl)-2, carbamate de methyle
   * (4-Butyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester
   * 5-Butyl-2-(carbomethoxyamino)benzimidazole
   * Carbamic acid, (5-butyl-1H-benzimidazol-2-yl)-, methyl ester
   * Helmatac
   * Methyl 5-butyl-2-benzimidazolecarbamate
   * Parbendazole
   * PBDZ
   * SKF 29044
   * Verminum
   * Worm Guard
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3657267
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issue)/page/year: 77,379,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3657267
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   AUVJA2 Australian Veterinary Journal.  (Australian Veterinary Assoc.,
   Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 
     1927-  Volume(issue)/page/year: 46,297,1970
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - cattle
DOSE/DURATION           : >1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AUVJA2 Australian Veterinary Journal.  (Australian Veterinary Assoc.,
   Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 
     1927-  Volume(issue)/page/year: 46,297,1970
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - cattle
DOSE/DURATION           : 450 mg/kg/6D-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
REFERENCE :
   AUVJA2 Australian Veterinary Journal.  (Australian Veterinary Assoc.,
   Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 
     1927-  Volume(issue)/page/year: 46,297,1970
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 7-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - gastrointestinal
   system
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issue)/page/year: 75,117,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   RMVEAG Recueil de Medecine Veterinaire.  (Masson Pub. USA, Inc., Year Book
   Medical Pub., 35 E. Wacker Dr., Chicago IL 60601)  V.1-    1824-
   Volume(issue)/page/year: 152,467,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issue)/page/year: 76,147,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issue)/page/year: 75,309,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 90 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,491,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 400 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issue)/page/year: 77,379,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issue)/page/year: 75,309,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 16 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issue)/page/year: 75,309,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 130 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   COVEAZ Cornell Veterinarian.  (Cornell Univ. New York State College of
   Veterinary Medicine, Ithaca, NY 14853)  V.1-    1911-
   Volume(issue)/page/year: 64(Suppl 4),104,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 780 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   COVEAZ Cornell Veterinarian.  (Cornell Univ. New York State College of
   Veterinary Medicine, Ithaca, NY 14853)  V.1-    1911-
   Volume(issue)/page/year: 64(Suppl 4),104,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 60 mg/kg
SEX/DURATION            : female 21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - physical
REFERENCE :
   COVEAZ Cornell Veterinarian.  (Cornell Univ. New York State College of
   Veterinary Medicine, Ithaca, NY 14853)  V.1-    1911-
   Volume(issue)/page/year: 64(Suppl 4),41,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 30 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   COVEAZ Cornell Veterinarian.  (Cornell Univ. New York State College of
   Veterinary Medicine, Ithaca, NY 14853)  V.1-    1911-
   Volume(issue)/page/year: 64(Suppl 4),56,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 2,67,1980
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - domestic Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976
 
                            *** END OF RECORD ***