*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DD6520500
CHEMICAL NAME           : 2-Benzimidazolecarbamic acid, 5-(phenylthio)-, methyl
                          ester
CAS REGISTRY NUMBER     : 43210-67-9
LAST UPDATED            : 199606
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C15-H13-N3-O2-S
MOLECULAR WEIGHT        : 299.37
WISWESSER LINE NOTATION : T56 BM DNJ CMVO1 GSR
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Carbamic acid, (5-(phenylthio)-1H-benzimidazol-2-yl)-, methyl ester
   * Fenbendazol
   * Fenbendazole
   * HOE 881
   * Panacur
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSSCBG Pesticide Science.  (Blackwell Scientific Pub. Ltd., POB 88, Oxford,
   UK)  V.1-    1970-  Volume(issue)/page/year: 8,550,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSSCBG Pesticide Science.  (Blackwell Scientific Pub. Ltd., POB 88, Oxford,
   UK)  V.1-    1970-  Volume(issue)/page/year: 8,550,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSSCBG Pesticide Science.  (Blackwell Scientific Pub. Ltd., POB 88, Oxford,
   UK)  V.1-    1970-  Volume(issue)/page/year: 8,550,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSSCBG Pesticide Science.  (Blackwell Scientific Pub. Ltd., POB 88, Oxford,
   UK)  V.1-    1970-  Volume(issue)/page/year: 8,550,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSSCBG Pesticide Science.  (Blackwell Scientific Pub. Ltd., POB 88, Oxford,
   UK)  V.1-    1970-  Volume(issue)/page/year: 8,550,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - pig
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSSCBG Pesticide Science.  (Blackwell Scientific Pub. Ltd., POB 88, Oxford,
   UK)  V.1-    1970-  Volume(issue)/page/year: 8,550,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSSCBG Pesticide Science.  (Blackwell Scientific Pub. Ltd., POB 88, Oxford,
   UK)  V.1-    1970-  Volume(issue)/page/year: 8,550,1977
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42 gm/kg/14D-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Liver - changes in liver weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   VHTODE Veterinary and Human Toxicology.  (American College of Veterinary and
   Comparative Toxicology, Publication Office, Comparative Toxicology,
   Manhattan, KS 66506)  V.19-    1977-  Volume(issue)/page/year: 34,411,1992
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 17500 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 343,185,1995
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 2,67,1980
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 2 mg/L
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976
 
                            *** END OF RECORD ***