*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DE4200000
CHEMICAL NAME : 1,2-Benzisothiazolin-3-one, 1,1-dioxide
CAS REGISTRY NUMBER : 81-07-2
LAST UPDATED : 199701
DATA ITEMS CITED : 52
MOLECULAR FORMULA : C7-H5-N-O3-S
MOLECULAR WEIGHT : 183.19
WISWESSER LINE NOTATION : T56 BSWMVJ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Anhydro-o-sulfaminebenzoic acid
* 3-Benzisothiazolinone 1,1-dioxide
* 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide
* o-Benzoic sulfimide
* Benzoic sulphimide
* o-Benzoic sulphimide
* o-Benzosulfimide
* Benzosulphimide
* o-Benzosulphimide
* Benzo-2-sulphimide
* o-Benzoyl sulfimide
* o-Benzoyl sulphimide
* 1,2-Dihydro-2-ketobenzisosulfonazole
* 1,2-Dihydro-2-ketobenzisosulphonazole
* 2,3-Dihydro-3-oxobenzisosulfonazole
* 2,3-Dihydro-3-oxobenzisosulphonazole
* Garantose
* Glucid
* Gluside
* Hermesetas
* 3-Hydroxybenzisothiazole-S,S-dioxide
* Insoluble saccharin
* Kandiset
* RCRA waste number U202
* Sacarina
* Saccharimide
* Saccharin
* Saccharina
* Saccharin acid
* Saccharine
* Saccharin insoluble
* Saccharinol
* Saccharinose
* Saccharol
* Sacharin
* Sucre edulcor
* Sucrette
* o-Sulfobenzimide
* o-Sulfobenzoic acid imide
* 2-Sulphobenzoic imide
* Zaharina
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 17 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 35,1364,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 365 gm/kg/1Y-I
TOXIC EFFECTS :
Blood - normocytic anemia
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 36,81,1987
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2008 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 40,583,1951
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 548 gm/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 24,197,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9600 mg/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
10,363,1956
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
11,212,1957
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 16800 mg/kg
SEX/DURATION : multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 8,285,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 101 gm/kg
SEX/DURATION : female 1-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
DBTEAD Diabete. (Le Raincy, France) V.1-22, 1953-74. Discontinued.
Volume(issue)/page/year: 17,103,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 252 gm/kg
SEX/DURATION : multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
DBTEAD Diabete. (Le Raincy, France) V.1-22, 1953-74. Discontinued.
Volume(issue)/page/year: 17,103,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 155 mg/kg
SEX/DURATION : female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
IIZAAX Iwate Igaku Zasshi. Journal of the Iwate Medical Association. (c/o
Iwate Ika Daigaku, 19-1 Uchimaru, Morioka, 020, Japan) V.1- 1947-
Volume(issue)/page/year: 16,330,1964
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 2 mg/plate
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
198,944,1977
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 4 gm/L
REFERENCE :
JEGPAY Journal of the Egyptian Public Health Association. (Egyptian Public
Health Assoc., Shousha Bldg., Bloc. A, 31 Sharia 26 July, App. 116, Cairo,
Egypt) V.1- 1926- Volume(issue)/page/year: 54,154,1979
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 200 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 294,263,1981
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 300 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
11,497,1988
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 140 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 13,2389,1992
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1000 ppm
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
200,543,1978
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 5 mmol/L
REFERENCE :
ICDBEO In Vitro Cellular and Developmental Biology. (Tissue Culture Assoc.,
19110 Montgomery Village Ave., Suite 300, Gaithersburg, MD 20879) V.21-
1985- Volume(issue)/page/year: 21,402,1985
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 3 mmol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 100 pmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 5,1547,1984
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
ICDBEO In Vitro Cellular and Developmental Biology. (Tissue Culture Assoc.,
19110 Montgomery Village Ave., Suite 300, Gaithersburg, MD 20879) V.21-
1985- Volume(issue)/page/year: 21,402,1985
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 40500 mg/kg(60D
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
13,259,1981
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 750 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 103,49,1982
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 100 mg/kg
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 5,355,1982
TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION : 2500 mg/kg
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
198,944,1977
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 168 gm/kg/24W (Continuous)
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 25,124,1987
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 30 mg/L
REFERENCE :
HDSKEK Hiroshima Daigaku Sogo Kagakubu Kiyo, 4: Kiso, Kankyo Kagaku Kenkyu.
Bulletin of the Faculty of Integrated Arts and Sciences, Hiroshima
University, Series 4: Fundamental and Environmental Sciences. (1-1-89
Higashisenda-machi, Naka-ku, Hiroshima 730, Japan) V.6- 1980-
Volume(issue)/page/year: 10,63,1985
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 7500 mg/kg
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 35,1364,1979
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1000 ppm
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
200,543,1978
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 mg/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
45,769,1982
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 22,111,1980
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 22,111,1980
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,334,1987
TOXICOLOGY REVIEW
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-
Volume(issue)/page/year: 18,306,1975
TOXICOLOGY REVIEW
TOANDB Toxicology Annual. (New York, NY) 1974/75-79. Discontinued.
Volume(issue)/page/year: -,71,1974
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,81,1975
TOXICOLOGY REVIEW
WMWOA4 Wiener Medizinische Wochenschrift. (Brueder Hollinek, Gallgasse 40,
A-1130 Vienna, Austria) V.1- 1851- Volume(issue)/page/year: 121,515,1971
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 25,173,1978
TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York,
NY 10003) V.1- 1973- Volume(issue)/page/year: 24,129,1983
TOXICOLOGY REVIEW
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266,
Phildelphia, PA 19103) V.1- 1978- Volume(issue)/page/year: 3,109,1981
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
4,674,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80507
No. of Facilities: 1556 (estimated)
No. of Industries: 37
No. of Occupations: 36
No. of Employees: 44968 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80507
No. of Facilities: 7348 (estimated)
No. of Industries: 107
No. of Occupations: 73
No. of Employees: 225094 (estimated)
No. of Female Employees: 97727 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; S cerevisiae gene
conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-aneuploidy; S
cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Weakly Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell
transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; E coli polA without
S9
EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal
translocation
EPA GENETOX PROGRAM 1988, Inconclusive: L5178Y cells in vitro-TK test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***