*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DE7985000
CHEMICAL NAME : Benzo(6,7)cyclohepta(1,2-c)pyrazole,
2,3,3a,4,5,6-hexahydro-2-acetyl-8-methoxy-3-phenyl-,
(+-)-
LAST UPDATED : 198910
DATA ITEMS CITED : 2
MOLECULAR FORMULA : C21-H22-N2-O2
MOLECULAR WEIGHT : 334.45
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* (+-)-2,3,3a,4,5,6-Hexahydro-2-acetyl-8-methoxy-3-phenylbenzo(6,7)cyclohe
pta(1,2-c)pyrazole
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 464 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including
Medicinal Chemistry. (Publications & Information Directorate, Council of
Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012,
India) V.14B- 1976- Volume(issue)/page/year: 20,135,1981
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 250 mg/kg
SEX/DURATION : female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including
Medicinal Chemistry. (Publications & Information Directorate, Council of
Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012,
India) V.14B- 1976- Volume(issue)/page/year: 20,135,1981
*** END OF RECORD ***