*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DE8255000
CHEMICAL NAME           : 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,
                          4,9-dihydro-4-(1-methyl-4-piperidinylidene)-
CAS REGISTRY NUMBER     : 34580-13-7
BEILSTEIN REFERENCE NO. : 3983897
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H19-N-O-S
MOLECULAR WEIGHT        : 309.45
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2
     -b)thiophen-10-one
   * HC 20-511
   * Ketotifen
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 179 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 30,13,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 108 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 30,13,1987
 
                            *** END OF RECORD ***