*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DE8747930
CHEMICAL NAME           : 1H-1,4-Benzodiazepine-3-carboxamide,
                          2,3-dihydro-7-chloro-N-methyl-2-oxo-5-phenyl-
CAS REGISTRY NUMBER     : 5606-59-7
BEILSTEIN REFERENCE NO. : 0690746
REFERENCE               : 5-25-08-00123 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H14-Cl-N3-O2
MOLECULAR WEIGHT        : 327.79
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   7-Chloro-2,3-dihydro-N-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-car
     boxamide
   * D-58M
   * 1-Methylcarbamoyldiazepam
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 840 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 29,134,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 29,134,1970
 
                            *** END OF RECORD ***