*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DE9470000
CHEMICAL NAME           : 3H-1,4-Benzodiazepine,
                          7-chloro-2-methylamino-5-phenyl-, 4-oxide, mixed with
                          sodium nitrite (1:1)
CAS REGISTRY NUMBER     : 104639-49-8
LAST UPDATED            : 199410
DATA ITEMS CITED        : 2
WISWESSER LINE NOTATION : T67 GN JN IHJ CG HN1&NO JO KR
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Chlordiazepoxide, nitrosated
   * Chlordiazepoxide mixed with sodium nitrite (1:1)
   * Sodium nitrite mixed with chlordiazepoxide (1:1)
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 gm/kg/50W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Liver - tumors
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 15,269,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 800 nmol/plate
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   12,81,1981
 
                            *** END OF RECORD ***