*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DE9720000
CHEMICAL NAME           : 1H-1,5-Benzodiazepine-2-thione,
                          2,3,4,5-tetrahydro-4-methyl-
CAS REGISTRY NUMBER     : 74389-71-2
BEILSTEIN REFERENCE NO. : 0784137
REFERENCE               : 5-24-02-00518 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C10-H12-N2-S
MOLECULAR WEIGHT        : 192.30
WISWESSER LINE NOTATION : T67 GMY KM&TJ HUS J1
SYNONYMS/TRADE NAMES :
   * 4-Methyl-1H-tetrahydro-1,5-benzodiazepine-2-thione
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - analgesia
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   31,615,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 458 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - analgesia
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   31,615,1979
 
                            *** END OF RECORD ***