*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DF1925000
CHEMICAL NAME           : 2H-1,4-Benzodiazepin-2-one,
                          7-chloro-1,3-dihydro-5-phenyl-, 4-oxide
CAS REGISTRY NUMBER     : 963-39-3
BEILSTEIN REFERENCE NO. : 0755892
REFERENCE               : 5-24-04-00295 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C15-H11-Cl-N2-O2
MOLECULAR WEIGHT        : 286.73
WISWESSER LINE NOTATION : T67 GMV JN IHJ CG JO KR
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-, 4-oxide
   * 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one-4-oxide
   * Demoxepam
   * 1,3-Dihydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one 4-oxide
   * NSC-46077
   * Ro 5-2092
   * Ro 5-2092 lactam
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTCEA9 Current Therapeutic Research, Clinical & Experimental.  (Therapeutic
   Research Press, Inc., POB 514, Tenafly, NJ 07670)  V.1-    1959-
   Volume(issue)/page/year: 7,590,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   26RAAN "Benzodinzenines,"  Garattini, S., et al.,  New York, Raven Press,
   1973  Volume(issue)/page/year: -,39,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTCEA9 Current Therapeutic Research, Clinical & Experimental.  (Therapeutic
   Research Press, Inc., POB 514, Tenafly, NJ 07670)  V.1-    1959-
   Volume(issue)/page/year: 7,590,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTCEA9 Current Therapeutic Research, Clinical & Experimental.  (Therapeutic
   Research Press, Inc., POB 514, Tenafly, NJ 07670)  V.1-    1959-
   Volume(issue)/page/year: 7,590,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 628 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTCEA9 Current Therapeutic Research, Clinical & Experimental.  (Therapeutic
   Research Press, Inc., POB 514, Tenafly, NJ 07670)  V.1-    1959-
   Volume(issue)/page/year: 7,590,1965
 
                            *** END OF RECORD ***