*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DF9484500
CHEMICAL NAME           : Benzo(a)heptalen-9(5H)-one,
                          6,7-dihydro-7,10-diamino-1,2,3-trimethoxy-
LAST UPDATED            : 198712
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H22-N2-O4
MOLECULAR WEIGHT        : 342.43
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Colchicinamide, desacetyl-
   * Desacetylcolchicinamide
   * 6,7-Dihydro-7,10-diamino-1,2,3-trimethoxybenzo(a)heptalen-9(5H)-one
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   PHTXA6 Pharmacology and Toxicology.  English translation of FATOAO.  (New
   York, NY)  V.20-22, 1957-59.  Discontinued.  Volume(issue)/page/year:
   20,284,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 253 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   PHTXA6 Pharmacology and Toxicology.  English translation of FATOAO.  (New
   York, NY)  V.20-22, 1957-59.  Discontinued.  Volume(issue)/page/year:
   20,284,1957
 
                            *** END OF RECORD ***