*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DG0935000
CHEMICAL NAME           : Benzoic acid, 2-(acetyloxy)-, mixed with
                          3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione, and
                          N-(4-ethoxyphenyl)acetamide
CAS REGISTRY NUMBER     : 8003-03-0
OTHER CAS REGISTRY NOS. : 91925-29-0
LAST UPDATED            : 199509
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H13-N-O2.C9-H8-O4.C8-H10-N4-O2
MOLECULAR WEIGHT        : 553.63
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * APC
   * APC (pharmaceutical)
   * Ascophen
   * Askophen
   * Aspirin, phenacetin and caffeine
   * Citramon
   * Empirin compound
   * NCI-C02697
   * Oscophen
   * P-A-C Compound
   * Thomapyrin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 15,139,1981
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 382 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-67,1978

                          *** STATUS IN U.S. ***
 
   NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-67,78

   NCI Carcinogenesis Bioassay (feed);no evidence:mouse
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-67,78

 
                            *** END OF RECORD ***