*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DG1575200
CHEMICAL NAME           : Benzoic acid, 4-amino-2-chloro-,
                          2-(diethylamino)ethyl ester, hydrochloride
CAS REGISTRY NUMBER     : 3858-89-7
LAST UPDATED            : 199504
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C13-H19-Cl-N2-O2.Cl-H
MOLECULAR WEIGHT        : 307.25
WISWESSER LINE NOTATION : ZR CG DVO2N2&2 &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 4-Amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester hydrochloride
   * Chloroprocaine hydrochloride
   * 2-Chloroprocaine hydrochloride
   * 2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate hydrochloride
   * Nesecaine-CE
   * Nesacaine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraspinal
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 9677 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   AACRAT Anesthesia and Analgesia (New York).  (Elsevier Science Pub. Co.,
   Inc., 52 Vanderbilt Ave., New York, NY 10017)  V.36-    1957-
   Volume(issue)/page/year: 66,677,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 266 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   54,501,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 75,215,1955
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMPCAS Journal of Medicinal and Pharmaceutical Chemistry.  (Washington, DC)
   V.1-5, 1959-62.  For publisher information, see JMCMAR.
   Volume(issue)/page/year: 3,525,1961

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5336
       No. of Facilities: 9 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 166 (estimated)
       No. of Female Employees: 105 (estimated)

 
                            *** END OF RECORD ***