*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DG2100000
CHEMICAL NAME : Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester
CAS REGISTRY NUMBER : 59-46-1
BEILSTEIN REFERENCE NO. : 0913480
REFERENCE : 4-14-00-01138 (Beilstein Handbook Reference)
LAST UPDATED : 199707
DATA ITEMS CITED : 25
MOLECULAR FORMULA : C13-H20-N2-O2
MOLECULAR WEIGHT : 236.35
WISWESSER LINE NOTATION : ZR DVO2N2&2
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* p-Aminobenzoic acid 2-diethylaminoethyl ester
* 4-Aminobenzoic acid diethylaminoethyl ester
* p-Aminobenzoyldiethylaminoethanol
* Diethylaminoethyl p-aminobenzoate
* beta-Diethylaminoethyl 4-aminobenzoate
* 2-Diethylaminoethyl p-aminobenzoate
* 2-Diethylaminoethylester kyseliny p-aminobenzoove
* Duracaine
* Gerovital
* Nissocaine
* Procain
* Procaine
* Procaine, base
* Spinocaine
* Vitamin H3
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 147 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 1600 ug/kg
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - stiffness
Behavioral - rigidity (including catalepsy)
REFERENCE :
JNNPAU Journal of Neurology, Neurosurgery and Psychiatry. (British Medical
Journal, POB 560B, Kennebunkport, ME 04046) V.7- 1944-
Volume(issue)/page/year: 34,20,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 104,388,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 350 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - excitement
Behavioral - rigidity (including catalepsy)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 16,1275,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 124 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:
2,213,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 29,425,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 45 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - local anesthetic
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 45,382,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 530 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
53,2S,1957
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 143 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
BDHU** "Nachprufung der Toxicitat von Novocain und Tutocain bei
Chloralisierten Tieren, Dissertation," Barke, A., Pharmakologischen Institut
der Tierarztlichen Hochschule zu Hannover, Fed. Rep. Ger., 1936
Volume(issue)/page/year: -,-,1936
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
BDHU** "Nachprufung der Toxicitat von Novocain und Tutocain bei
Chloralisierten Tieren, Dissertation," Barke, A., Pharmakologischen Institut
der Tierarztlichen Hochschule zu Hannover, Fed. Rep. Ger., 1936
Volume(issue)/page/year: -,-,1936
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 225 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
BDHU** "Nachprufung der Toxicitat von Novocain und Tutocain bei
Chloralisierten Tieren, Dissertation," Barke, A., Pharmakologischen Institut
der Tierarztlichen Hochschule zu Hannover, Fed. Rep. Ger., 1936
Volume(issue)/page/year: -,-,1936
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 21500 ug/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
BDHU** "Nachprufung der Toxicitat von Novocain und Tutocain bei
Chloralisierten Tieren, Dissertation," Barke, A., Pharmakologischen Institut
der Tierarztlichen Hochschule zu Hannover, Fed. Rep. Ger., 1936
Volume(issue)/page/year: -,-,1936
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 230 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
BDHU** "Nachprufung der Toxicitat von Novocain und Tutocain bei
Chloralisierten Tieren, Dissertation," Barke, A., Pharmakologischen Institut
der Tierarztlichen Hochschule zu Hannover, Fed. Rep. Ger., 1936
Volume(issue)/page/year: -,-,1936
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 106,37,1952
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraspinal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 54,137,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville
Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year:
12,190,1932
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 144,197,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville
Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year:
12,190,1932
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 131,171,1928
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - excitement
Cardiac - pulse rate
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 144,197,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraspinal
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 45,291,1932
*** REVIEWS ***
TOXICOLOGY REVIEW
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville
Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year:
12,190,1932
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7542
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 432 (estimated)
No. of Female Employees: 203 (estimated)
*** END OF RECORD ***