*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DG2450000
CHEMICAL NAME           : Benzoic acid, p-amino-, ethyl ester
CAS REGISTRY NUMBER     : 94-09-7
BEILSTEIN REFERENCE NO. : 0638434
REFERENCE               : 4-14-00-01129 (Beilstein Handbook Reference)
LAST UPDATED            : 199706
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C9-H11-N-O2
MOLECULAR WEIGHT        : 165.21
WISWESSER LINE NOTATION : ZR DVO2
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Human
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Americaine
   * p-Aminobenzoic acid ethyl ester
   * 4-Aminobenzoic acid, ethyl ester
   * Anestezin
   * Anaesthesin
   * Anesthesin
   * Anesthone
   * Benzocaine
   * Ethyl aminobenzoate
   * Ethyl p-aminobenzoate
   * Ethyl 4-aminobenzoate
   * Ethylester kyseliny p-aminobenzoove
   * Keloform
   * Norcain
   * Orthesin
   * Parathesin
   * Topcaine
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2%/48H
REACTION SEVERITY       : Mild
REFERENCE :
   JSCCA5 Journal of the Society of Cosmetic Chemists.  (Soc. of Cosmetic
   Chemists, 1995 Broadway, Suite 1701, New York, NY 10023)  V.1-    1947-
   Volume(issue)/page/year: 28,357,1977
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   263,454,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3042 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (2),34,1996
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (2),34,1996
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 216 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,900,1974
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,33,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   54,7740,1989

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81723
       No. of Facilities: 293 (estimated)
       No. of Industries: 8
       No. of Occupations: 7
       No. of Employees: 2005 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81723
       No. of Facilities: 1499 (estimated)
       No. of Industries: 12
       No. of Occupations: 17
       No. of Employees: 167623 (estimated)
       No. of Female Employees: 146838 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***