*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DG4425000
CHEMICAL NAME           : Benzoic acid,
                          2-(4-bis(2-chloroethyl)amino-2-methyl)phenylazo-
CAS REGISTRY NUMBER     : 4213-40-5
BEILSTEIN REFERENCE NO. : 3443540
REFERENCE               : 4-16-00-00536 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C18-H19-Cl2-N3-O2
MOLECULAR WEIGHT        : 380.30
WISWESSER LINE NOTATION : QVR BNUNR B1 DN2G2G
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Azobenzene-2-carboxylic acid, 4'-(di-2''-chloroethylamino)-2'-methyl-
   * Azo-mustard
   * Benzoic acid, 2-(4-bis(2-chloroethyl)amino-1-(o-tolyl))azo-
   * o-(4-Bis(beta-chloroethyl)amino-o-tolylazo)benzoic acid
   * NSC-16498
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   50,243,1973
 
TYPE OF TEST            : LD10 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 17,56,1962
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 950 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - leukopenia
   Blood - thrombocytopenia
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,202,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 950 ug/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - thrombocytopenia
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,202,1965

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***