*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : DG5015010 CHEMICAL NAME : Benzoic acid, 4-chloro-, 3-ethyl-7-methyl-3,7-diazabicyclo(3.3.1)non-9-yl ester, monohydrochloride, syn- CAS REGISTRY NUMBER : 96480-44-3 LAST UPDATED : 199510 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C17-H23-Cl-N2-O2.Cl-H MOLECULAR WEIGHT : 359.33 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * syn-4-Chlorobenzoic acid 3-ethyl-7-methyl-3,7-diazabicyclo(3.3.1)non-9-yl ester hydrochloride * NK-1556 * RGH 2957 * Yutac *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 11,516,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 11,516,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 22,463,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 11,516,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 10920 mg/kg/91D-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - chronic pulmonary edema Endocrine - changes in spleen weight Related to Chronic Data - death REFERENCE : CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 11,516,1993 *** END OF RECORD ***