*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : DG3065000 CHEMICAL NAME : Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, hydrochloride CAS REGISTRY NUMBER : 5875-06-9 LAST UPDATED : 199504 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C16-H26-N2-O3.Cl-H MOLECULAR WEIGHT : 330.90 WISWESSER LINE NOTATION : 3OR BZ DVO2N2&2 &GH COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Alcaine * 3-Amino-4-propoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride * beta-(Diethylamino)ethyl 3-amino-4-n-propoxybenzoate hydrochloride * 2-Diethylaminoethyl 3-amino-4-propoxybenzoate hydrochloride * Keracaine * Ophthain * Ophthaine hydrochloride * Proparacaine hydrochloride * Proxymetacaine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 64 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3371 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3223 No. of Facilities: 412 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3442 (estimated) No. of Female Employees: 2127 (estimated) *** END OF RECORD ***