*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DG5775000
CHEMICAL NAME           : Benzoic acid, p-(cyclohexyloxy)-,
                          3-(2-methylpiperidino)propyl ester, hydrochloride
CAS REGISTRY NUMBER     : 537-61-1
LAST UPDATED            : 199404
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C22-H33-N-O3.Cl-H
MOLECULAR WEIGHT        : 396.02
WISWESSER LINE NOTATION : T6NTJ B1 A3OVR DO- AL6TJ &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * p-Cyclohexyloxybenzoic acid 3-(2-methylpiperidino)propyl ester  
   hydrochloride
   * Cyclomethycaine hydrochloride
   * N-(3-Hydroxypropyl)pipecoline hydrochloride p-cyclohexyloxybenzoic acid  
   ester
   * 3-(2-Methylpiperidino)propyl p-(cyclo-hexyloxy)benzoate hydrochloride
   * 1-Piperidinepropanol, 2-methyl-, p-(cyclohexyloxy)benzoate, hydrochloride
   * Surfacaine hydrochloride
   * Surfathesin hydrochloride
   * Topocaine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2340 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,37,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 447 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACSAT Journal of the American Chemical Society.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1879-  Volume(issue)/page/year: 68,2592,1946
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 54 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACSAT Journal of the American Chemical Society.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1879-  Volume(issue)/page/year: 68,2592,1946

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81535
       No. of Facilities: 58 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 633 (estimated)

 
                            *** END OF RECORD ***