*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DH2080000
CHEMICAL NAME : Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
CAS REGISTRY NUMBER : 552-94-3
BEILSTEIN REFERENCE NO. : 2590908
REFERENCE : 4-10-00-00165 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C14-H10-O5
MOLECULAR WEIGHT : 258.24
WISWESSER LINE NOTATION : QVR BOVR BQ
COMPOUND DESCRIPTOR : Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Diacesal
* Diplosal
* Disalcid
* Disalicylic acid
* Disalyl
* Nobacid
* NSC-49171
* SAA
* Salical
* Salicylic acid, bimolecular ester
* Salicyloylsalicylic acid
* Salicylsalicylic acid
* o-Salicylsalicylic acid
* Salina
* Saloxium
* Salsalate
* Salysal
* Sasapirin
* Sasapyrin
* Sasapyrine
* Sasapyrinum
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2229 mg/kg/2Y-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
107,116,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1020 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 22,1101,1980
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 665 mg/kg
SEX/DURATION : female 17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
29,250,1971
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80509
No. of Facilities: 105 (estimated)
No. of Industries: 2
No. of Occupations: 7
No. of Employees: 3179 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80509
No. of Facilities: 34 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 629 (estimated)
No. of Female Employees: 291 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***