*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DH2190000
CHEMICAL NAME : Benzoic acid, p-hydroxy-, ethyl ester
CAS REGISTRY NUMBER : 120-47-8
BEILSTEIN REFERENCE NO. : 1101972
REFERENCE : 4-10-00-00367 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C9-H10-O3
MOLECULAR WEIGHT : 166.19
WISWESSER LINE NOTATION : QR DVO2
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Aseptoform E
* Bonomold OE
* p-Carbethoxyphenol
* Easeptol
* Ester etylowykwasu p-hydroksybenzoesowego
* Ethylester kyseliny p-hydroxybenzoove
* Ethyl p-hydroxybenzoate
* Ethyl p-oxybenzoate
* Ethyl paraben
* Ethyl parasept
* p-Hydroxybenzoic acid ethyl ester
* p-Hydroxybenzoic ethyl ester
* Nipagin A
* Nipagina A
* Nipazin A
* p-Oxybenzoesaeureaethylester
* Solbrol A
* Tegosept E
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AOGLAR Acta Obstetrica et Gynaecologica Japonica, English Edition. (Tokyo,
Japan) V.16-23, 1969-76. For publisher information, see NISFAY.
Volume(issue)/page/year: 22,94,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068
Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 14,301,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRSTAT Drug Standards. (Washington, DC) V.19-28, 1951-60. For publisher
information, see JPMSAE. Volume(issue)/page/year: 20,89,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 504 gm/kg/12W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 45,260,1956
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 45600 mg/kg
SEX/DURATION : female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
AOGLAR Acta Obstetrica et Gynaecologica Japonica, English Edition. (Tokyo,
Japan) V.16-23, 1969-76. For publisher information, see NISFAY.
Volume(issue)/page/year: 22,94,1975
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 mmol/L
REFERENCE :
ZBPIA9 Zentralblatt fuer Bakteriologie, Parasitenkunde,
Infektionskrankheiten und Hygiene, Abteilung II. Naturwissenschaftliche:
Allgemeine, Landwirtschaftliche und Technische Mikrobiologie. (Jena, Ger.
Dem. Rep.) V.107-132, 1952-77. Volume(issue)/page/year: 112,226,1959
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 250 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(96),55,1978
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 440 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year:
27,95,1981
*** REVIEWS ***
TOXICOLOGY REVIEW
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 4,575,1954
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82869
No. of Facilities: 103 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 3241 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82869
No. of Facilities: 307 (estimated)
No. of Industries: 6
No. of Occupations: 7
No. of Employees: 4591 (estimated)
No. of Female Employees: 1145 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***