*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DH2528300
CHEMICAL NAME           : Benzoic acid, p-hydroxy-,
                          (5-nitrofurfurylidene)hydrazide
CAS REGISTRY NUMBER     : 965-52-6
BEILSTEIN REFERENCE NO. : 1352180
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C12-H9-N3-O5
MOLECULAR WEIGHT        : 275.24
WISWESSER LINE NOTATION : T5OJ BNW E1UNMVR DQ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benzoic acid, 4-hydroxy-, ((5-nitro-2-furanyl)methylene)hydrazide
   * Diarlidan
   * Dicoferin
   * Ercefurol
   * Ercefuryl
   * p-Hydroxybenzoic acid (5-nitrofurfurylidene)hydrazide
   * Nifuroxazid
   * Nifuroxazide
   * (Nitro-5' furfurylidene-2') hydroxy-4 benzhydrazide
   * R.C. 27-109
   * RC 30-109
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 21,287,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - respiratory depression
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 16,663,1964
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 157,1,1985
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 250 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 187,55,1987
 
                            *** END OF RECORD ***