*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DH3850000
CHEMICAL NAME : Benzoic acid, methyl ester
CAS REGISTRY NUMBER : 93-58-3
LAST UPDATED : 199806
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C8-H8-O2
MOLECULAR WEIGHT : 136.16
WISWESSER LINE NOTATION : 1OVR
COMPOUND DESCRIPTOR : Natural Product
SYNONYMS/TRADE NAMES :
* Essence of niobe
* Methyl benzenecarboxylate
* Methylester kyseliny benzoove
* Niobe oil
* Oil of niobe
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1177 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active
Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966-
Volume(issue)/page/year: 18,69,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3330 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - excitement
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 10 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 84,358,1945
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2170 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Skin and Appendages - hair
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 84,358,1945
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 4100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,937,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 17400 mg/kg/60D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 49(11),85,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1650
No. of Facilities: 61 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 1002 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1650
No. of Facilities: 4188 (estimated)
No. of Industries: 51
No. of Occupations: 60
No. of Employees: 73641 (estimated)
No. of Female Employees: 25030 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***