*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DH6910000
CHEMICAL NAME           : Benzoic acid, thio-, S-ester with
                          N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydro
                          xy- 2-mercapto-1-methyl-1-butenyl)formamide
                          dihydrogen phosphate (ester)
CAS REGISTRY NUMBER     : 22457-89-2
BEILSTEIN REFERENCE NO. : 0771326
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H23-N4-O6-P-S
MOLECULAR WEIGHT        : 466.49
WISWESSER LINE NOTATION : T6N CNJ B1 DZ E1VMY1&UYSVR&2OPQQO
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benfotiamine
   * Benzoylthiamine monophosphate
   * Benzoylthiamine O-monophosphate
   * S-Benzoylthiamine monophosphate
   * Berdi
   * Betivina
   * Bietamine
   * Biotamin
   * BTMP
   * 8088 C.B.
   * Neurostop
   * Nitanevril
   * Tabiomyl
   * Thiamine monophosphate benzoyl
   * Vitanevril
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,781,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical,
   Medical and Dental Supply Exporters' Assoc.,  1968 Volume(issue)/page/year:
   -,78,1968
 
                            *** END OF RECORD ***