*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DI2370000
CHEMICAL NAME           : Benzo(b)-1,5-naphthyridin-10-amine,
                          7-chloro-N-(3-((2-chloroethyl)thio)propyl)-2-methoxy-
                          , hydrochloride
CAS REGISTRY NUMBER     : 38915-31-0
LAST UPDATED            : 199012
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C18-H19-Cl2-N3-O-S.Cl-H
MOLECULAR WEIGHT        : 432.82
WISWESSER LINE NOTATION : T C666 BN GNJ FO1 IM3S2G MG &GH
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   *   7-Chloro-10-((3-((2-chloroethyl)thio)propyl)amino)-2-methoxybenzo(b)-1,5
     -naphthyridine HCl
   * ICR 342
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10821 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,4875,1979

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation

 
                            *** END OF RECORD ***