*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DI4605000
CHEMICAL NAME           : Benzonitrile,
                          2-(2-hydroxy-3-((2-(1H-indol-3-yl)-1,1-dimethylethyl)
                          amino)propoxy)-, monohydrochloride
CAS REGISTRY NUMBER     : 70369-47-0
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H25-N3-O2.Cl-H
MOLECULAR WEIGHT        : 399.96
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bucindolol hydrochloride
   *   2-(2-Hydroxy-3-((2-(3-indolyl)-1,1-dimethylethyl)amino)propoxy)benzonitr
     ile hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,1,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   NDADD8 New Drugs Annual: Cardiovascular Drugs.  (New York, NY)  V.1-2,
   1983-84.  For publisher information, see NCDREP.  Volume(issue)/page/year:
   1,1,1983
 
                            *** END OF RECORD ***